“Under fasting conditions, the oral bioavailability of paliperidone (the “new and improved!” risperidone, though it’s actually just an active metabolite of risperidone—and both paliperidone and risperidone are equally efficacious, which means paliperidone is not “better”) is only 28%, but this can be approximately doubled by taking it with a high-fat, high-calorie meal.” [Biological Therapies in Psychiatry (a useful, concise newsletter that does not have any drug company ads), July 2008: Vol 31, No 7]

Antipsychotic medications are already associated with a metabolic syndrome that consists of weight gain. How can anyone justify prescribing a weight-inducing medication that essentially requires a weight-inducing meal for absorption? Particularly when it is no “better” than its soon-to-be generic older brother?